The surface of gold nanorods (GNRs) with average aspect ratio 3.5 functionalized by poly(styrene sulfonate) for the attachment of goat anti-h-IgG yielded GNR molecular probes, which exhibited the rapid and sensitive detection of h-IgG by localized surface plasmon absorption (LSPR). The detection limit of the present method is 60 ng mL−1. This novel method using GNRs with different aspect ratios is simple and sensitive, may provide a novel optical multiplex biosensor platform, and has broad potential applications in immunoassay and disease diagnosis.
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Wang et al. (2007) studied this question.
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