In conventional ESI, electrochemical reactions occur at the interface between the emitter electrode and the solution. This study deals with “bipolar electrospray ionization,” in which positive and negative ions are generated simultaneously, with the aim of preventing electrochemical reactions in the emitter. The voltage-current and flow rate-current relationships of bipolar electrospray were found to be similar to the standard electrospray. The application of bipolar ESI to the mass spectrometry of melittin without electrochemical oxidation is demonstrated.
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Komori et al. (2023) studied this question.
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