The one-pot synthesis of 1,1,1-trifluoro- and 1,1-difluoro-2,2-diarylethanes from arenes and fluorinated hemiacetals in the BF(3)-H(2)O system is described. The reaction is simple, clean, and convenient, eliminating the use of organic solvents and other expensive acid systems. BF(3)-H(2)O is economic, is easy to prepare, and offers ample acidity required for this reaction.
No takes yet. Share an insight, caveat, or question.
Prakash et al. (2011) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: