Rapid chiral method development using microfluidic multiparallel HPLC is illustrated with several examples of ‘real world’ pharmaceutical intermediates for which speed was critical for successful process development. It is shown that this rapid chiral method development approach is suitable for support of high throughput screening of enantioselective catalytic hydrogenation reactions and other high throughput experimentation initiatives in pharmaceutical process research.
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Sajonz et al. (2008) studied this question.
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