Poly (PEGDMA-MAA) copolymeric micro and nanoparticles for oral insulin delivery: A molecular mechanistic revisit

Poly(ethylene glycol) dimethacrylate (PEGDMA) and methacrylic acid (MAA) based micro and nanoparticles were prepared for oral insulin delivery. The reactional profiles of MAA, PEGDMA and PEGDMA-MAA were elucidated using molecular mechanics energy relationships (MMER) in vacuum and in a solvated system by exploring the spatial disposition of different concentrations of polymers with respect to each other. Furthermore, the incorporation of insulin within the polymeric matrix was modeled using connolly molecular surfaces. The computational results corroborated with the experimental and analytical data. The ability to effectively control blood glucose level coupled with the non toxic behavior of the nanoparticles renders them a potential candidate for insulin delivery.