β1-Adrenergic Receptor Polymorphisms: A Possible Genetic Predictor of Bisoprolol Response in Acute Coronary Syndrome

Figures

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  Figure 1.. Study flowchart representing enrollment, allocation, follow-up and analysis processes.

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  Figure 2.. Comparison of allele frequencies of the studied SNPs in Egyptians compared with other populations. (A) ADRB1 rs1801252 (light bars: Gly-allele, dark bars: Ser-allele), (B) ADRB1 rs1801253 (light bars: Gly-allele, dark bars: Arg-allele). Allele frequencies obtained from the 1000 Genome, Phase III data [28]. Egyptian study, El Gindy et al. 2022 [29].

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  Figure 3.. Bar chart presenting the changes in systolic and diastolic blood pressure after 4 weeks of bisoprolol treatment according to codon 389 genotype. P-values were computed from paired t-test between baseline (before treatment) and average BP readings during 4 weeks of treatment (post treatment). Showing a significant change of both systolic and diastolic blood pressure from baseline among the Arg389Arg carriers (p < 0.001 and p < 0.001, respectively), inconsistent with Gly389 carriers which showed no significant changer neither in systolic (p = 0.35) nor diastolic (p = 0.91) blood pressure. Data are presented as mean with SD Created by GraphPad Prism version 8.0.2 for Windows. BP: Blood pressure; mmHg: Millimeters of mercury.

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  Figure 4.. Boxplot presenting the percent change in blood pressure compared with baseline in response to bisoprolol by codon 389 genotype. P-values were computed from the general linear model. Showing a significant difference in percent change in blood pressure between Arg389Arg carriers and Gly389 carriers (p < 0.0001). Created by GraphPad Prism version 8.0.2 for Windows.

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  Figure 5.. Bar chart presenting the systolic and diastolic blood pressure changes after 4 weeks of bisoprolol treatment according to codon 49 genotype. P-values are computed from paired t test between baseline (before treatment) and average BP readings during 4 weeks of treatment (post treatment). BP, blood pressure; mmHg, millimeters of mercury. Data are presented as mean with SD. Created by GraphPad Prism version 8.0.2 for Windows.

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  Figure 6.. Heart rate changes after 4 weeks of bisoprolol treatment according to codon 389 genotype. The p-values are computed from paired t-test between baseline and week 4. Data are presented as mean with SD. Created by GraphPad Prism version 8.0.2 for Windows. bpm: Beat per minute; HR: Heart rate.