Key result
Dysregulated lipoprotein metabolism drives NAFLD pathogenesis, diagnosis, and potential therapeutic targets.
Understanding the complex intracellular and extracellular roles of apolipoproteins and lipoprotein metabolism provides crucial insights into the pathophysiology of NAFLD and identifies potential novel therapeutic targets.
May guide targeted NAFLD research on lipoprotein pathways; leaves open clinical translation pending prospective validation.
Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellular role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metabolism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD.
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Zhenghui et al. (2013) conducted a review in Nonalcoholic fatty liver disease (NAFLD). Lipoprotein metabolism was evaluated. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and its dysregulation plays a central role in the pathogenesis, diagnosis, and potential treatment of nonalcoholic fatty liver disease.
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