Interleukin and Interleukin Receptor Diversity: Role of Alternative Splicing

Alternative splicing is a fine-tuned process known for generating multiple functional variants from individual genes leading to protein diversity. The immune system utilizes pre-mRNA splicing to expand its gene function. Numerous immunologically relevant genes have been found to undergo alternative splicing, thus revealing a new source of complexity in the immune gene network. This review attempts to summarize the general features of alternative splicing and its role in the immune system along with a special focus on the available reports of alternative splicing in cytokines, mainly interleukins and their receptors and their regulatory significance.