Key result
Serotonin 5-HT2A receptors play a significant role in renal pathophysiology, and their pharmacological modulation presents a potential therapeutic strategy to attenuate the development of chronic kidney diseases.
Why the study?
CKD progression involves multiple pathways, but the association and pathophysiological mechanisms of the serotonin 5-HT2A receptor with progressive renal injury remain poorly understood.
Serotonin 5-HT2A receptor antagonism represents a potential novel therapeutic approach to halt the progression of chronic kidney disease by targeting multiple interrelated pathophysiological pathways.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for 5-HT2A modulation in CKD; prospective trials needed before clinical consideration.
Chronic kidney diseases (CKD) are an economic burden and occur worldwide in all age groups, and the advancement of kidney disease at some point leads to deregulate or influence the function of other body organs and to find a specific target to halt the disease progression which is a tedious challenge. Regardless of the underlying mechanisms, it is essential to consider and evaluate the involvement and association of individual endogenous mediators and environmental factors in the progression of CKD to accumulate the required knowledge. More than a dozen pathways leading to relentless progression of CKD have been identified so far, but the association of serotonin 5-HT 2A receptor with progressive renal injury is still under process. Scientific reports demonstrated that the 5-HT 2A receptor plays a significant role in renal metabolism, glomerular function, and renal vascular tone. So a better understanding of the evolving role of serotonin 5-HT 2A -mediated pathophysiological mechanisms of CKD may be a helpful tool to identify new therapeutic targets. In this review, we will discuss recent interventions, pharmacological target, and the possible implication of serotonin 5-HT 2A receptors with associated mechanistic trails leading to CKD.
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Kaur et al. (2020) conducted a review in Chronic kidney diseases. Serotonin 5-HT2A receptor modulators was evaluated. Serotonin 5-HT2A receptors play a significant role in renal pathophysiology, and their pharmacological modulation presents a potential therapeutic strategy to attenuate the development of chronic kidney diseases.
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