Key result
Miniaturized implantable sensor detects in-stent restenosis and differentiates plaque components in ex vivo samples.
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Self-reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re-block after deployment due to a wound response called in-stent restenosis (ISR). Herein, an implantable miniaturized sensor and telemetry system are developed that can detect this process, discern the different cell types associated with ISR, distinguish sub plaque components as demonstrated with ex vivo samples, and differentiate blood from blood clot, all on a silicon substrate making it suitable for integration onto a vascular stent. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells.
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Hoare et al. (2022) studied In-stent restenosis. Implantable miniaturized sensor and telemetry system was evaluated on Detection of in-stent restenosis, discerning associated cell types, distinguishing sub plaque components, and differentiating blood from clot. An implantable miniaturized sensor and telemetry system successfully detected in-stent restenosis and differentiated plaque components and cell types in ex vivo samples.
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