Amine directed Pd( ii )-catalyzed C–H bond functionalization under ambient conditions

Pd(II)-catalyzed C–H bond functionalizations that proceed under ambient conditions are a pivotal part of the future of chemical synthesis. Herein, an amine directed Pd(II)-catalyzed C–H bond functionalization strategy is described that generates a diversity of molecular frameworks via C–H carbonylation, C–H arylation and C–H amination. The new reactions work for a variety of substrates and are tolerant of delicate stereogenic centres and functionality. Furthermore, the new reactions can be sequenced to generate complex architectures from simple building blocks via iterative Pd(II)-catalyzed C–H bond functionalization.