C3b covalently bound to IgG demonstrates a reduced rate of inactivation by factors H and I.

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Natural release of covalently bound C3b from cell surfaces and the study of this phenomenon in the fluid-phase system.1984 · 39 citations
2. 2Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte1980 · 645 citations
3. 3Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution.1977 · 686 citations
4. 4Classical complement pathway activation by antipneumococcal antibodies leads to covalent binding of C3b to antibody molecules1983 · 43 citations