Ruthenium(II)-catalyzed reaction of N -sulfonylimines with methyl isocyanoacetate proceeds efficiently under neutral, mild conditions to give trans -2-imidazolines stereoselectively in high yields. 2,3-Diamino acids can be easily acquired via the hydrolysis of the imidazolines in excellent yields. A possible mechanism for the ruthenium-catalyzed aldol reaction of the imines under neutral conditions is discussed.
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Lin et al. (1997) studied this question.
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