Key result
The Gc1s allele of the vitamin D-binding protein significantly increased the risk of coronary artery disease (OR 1.45; p<0.02), whereas the Gc2 allele was associated with a decreased risk (OR 0.69; p<0.03).
Why the study?
Does vitamin D-binding protein (DBP) polymorphism affect the risk of coronary artery disease?
Case-Control (n=568)
Does vitamin D-binding protein (DBP) polymorphism affect the risk of coronary artery disease?
The Gc1s allele of the vitamin D-binding protein is associated with an increased risk of coronary artery disease, whereas the Gc2 allele appears protective.
The aim of the study was to assess the effect of vitamin D-binding protein (DBP) polymorphism on coronary artery disease (CAD). DBP phenotypes were identified in the groups: control (n = 306), men suffering from CAD (n = 154), and long-lived individuals (n = 108). Isoelectric focusing of DBP phenotypes in serum was performed on polyacrylamide gel. Distribution of DBP phenotypes in the study groups was found to be in Hardy-Weinberg equilibrium. Gc1s-1s phenotype and Gc1s allele frequency in CAD groups were significantly higher than in control, and Gc1s allele frequency was found significantly more often in CAD compared with long-lived group (p < 0.05). The Gc2 allele frequency in control was higher as compared with Gc2 frequency in CAD group (p < 0.05). The Gc2-2 phenotype was more frequent in long-lived survivors than in the CAD group (p < 0.05). It was found that the Gc1s allele significantly increased the risk of CAD with the odds ratio (OR) equal to 1.45 (p < 0.02) and showed Gc2 to be related with a decreased risk of CAD (OR = 0.69; p < 0.03). Authors review the role of DBP in resistance to atherosclerosis and cancer as the main longevity determinants.
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Stakišaitis et al. (2016) conducted a case-control in Coronary Artery Disease (n=568). Vitamin D-binding protein (DBP) polymorphism (Gc1s allele) vs. Control group / other alleles was evaluated on Risk of coronary artery disease (OR 1.45, p=<0.02). The Gc1s allele of the vitamin D-binding protein significantly increased the risk of coronary artery disease (OR 1.45; p<0.02), whereas the Gc2 allele was associated with a decreased risk (OR 0.69; p<0.03).
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