Az N-terminális pro-B natriureticus peptid jelentősége a felnőtt korú congenitalis szívbetegek gondozásában – Eredmények a CSONGRAD Regiszterből

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Adult congenital heart disease (n=70). Intervention: Elevated NT-proBNP vs. Normal or lower NT-proBNP. Primary outcome: Prediction of NYHA class III-IV heart failure (AUC 80%, p=0.001).

Nóra Ambrus; Kálmán Havasi; Krisztina Berek; Anita Kalapos; István Hartyánszky; Gábor Bogáts; Tamás Forster; Attila Nemes

doi:10.1556/650.2018.30942

January 1, 2018Orvosi HetilapOpen Access

Az N-terminális pro-B natriureticus peptid jelentősége a felnőtt korú congenitalis szívbetegek gondozásában – Eredmények a CSONGRAD Regiszterből

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Study Design

Type

Cross-Sectional (n=70)

Multicenter

No

Structured PICO

P

Population

70 adult patients with congenital heart disease underwent outpatient clinical, echocardiographic, and NT-proBNP evaluations to assess prognostic markers.

O

Outcome

Correlation of NT-proBNP levels with clinical and echocardiographic parameters (NYHA class, quality of life by visual analogue scale, left ventricular ejection fraction, right ventricular end-diastolic diameter, and arrhythmia)surrogate

Main Result

Effect estimate: AUC 80%

p-value: p=0.001

Limitations

Relatively small sample size
NT-proBNP cut-off values were based on international guidelines, not accounting for age-related differences
The studied population of 70 congenital heart disease patients was heterogeneous
Left ventricular ejection fraction could not be determined in some patients due to technical reasons
Small sample size
Heterogeneous population
Missing LV-EF in some patients (19%)
Use of non-age-specific cut-offs

Implication

NT-proBNP is a useful biomarker in adult patients with congenital heart disease for predicting reduced left ventricular ejection fraction and worse NYHA functional class.

Abstract

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Discussion

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Cite This Study

Ambrus et al. (2018) conducted a cross-sectional in Adult congenital heart disease (n=70). Elevated NT-proBNP vs. Normal or lower NT-proBNP was evaluated on Prediction of NYHA class III-IV heart failure (AUC 80%, p=0.001).

synapsesocial.com/papers/6a6f35cab27f15817826e7e8 https://doi.org/10.1556/650.2018.30942

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Az N-terminális pro-B natriureticus peptid jelentősége a felnőtt korú congenitalis szívbetegek gondozásában – Eredmények a CSONGRAD Regiszterből

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Az N-terminális pro-B natriureticus peptid jelentősége a felnőtt korú congenitalis szívbetegek gondozásában – Eredmények a CSONGRAD Regiszterből

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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