Inter‐relationships Between Levels of Plasma Oestradiol, Urinary Total Oestrogens and Blood Haemoglobin and Neutrophil Counts

Summary The inter‐relationships between levels of urinary total oestrogens, plasma oestradiol and blood haemoglobin and neutrophil levels were investigated in five women undergoing treatment with pituitary gonadotrophin hormone for infertility. Predicted values for urinary oestrogens were also calculated from the haemoglobin and neutrophil results. There was a positive correlation of plasma oestradiol with both actual and predicted concentrations of urinary oestrogens but there was substantial variation between patients. The levels of plasma and urinary oestrogens showed a significant positive correlation with the blood neutrophil counts, a negative but not significant correlation with the haemoglobin concentration, and a highly significant correlation with the ratio of the two observations. Again marked variation between subjects occurred. The use of these parameters for monitoring the treatment of infertile patients with human gonadotrophins is discussed.