The relationship of the ectopic presence of three placental proteins in the sera of patients with non-trophoblastic neoplasms was investigated. The proteins chorionic gonadotropin, placental lactogen, and placental alkaline phosphatase were measured using radioimmune and immunochemical assays which enabled specific and quantitative measurement of each peptide. The results indicate that the presence of each peptide was independent of the others, and that when more than one peptide was found, the concentration of each was independent of the others. These results suggest that the regulation of synthesis of these proteins is not under coordinate control analogous to a single operon in bacterial systems. These findings also indicate that each of these peptides may be used as an independent cancer marker.
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Sussman et al. (1974) studied this question.
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