Quinidine may act as an antigen causing systemic allergic-type vasculitis and acute renal failure characterized by eosinophilic infiltration and non-caseating granulomata.
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May signal quinidine-associated allergic vasculitis with renal failure; single case leaves open need for pharmacovigilance confirmation.
A case of systemic allergic-type vasculitis after the administration of quinidine and digoxin is described. The renal biopsy findings are unique in that they describe an arteritis with eosinophilic infiltration and non-caseating granulomata. We believe quinidine is the antigen that was responsible for the reported findings.
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Quin et al. (1988) studied this question.
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