Cells contain complex protein machinery that drives their repeated divisions, but they also have that prevent this from happening if conditions are not right. If their DNA is damaged, for example, the cell cycle is arrested. Now in a Perspective, Weinert synthesizes the results presented in three papers in this issue and describes a biochemical pathway that links for the first time the checkpoint proteins that sense DNA damage and the cyclin-dependent kinase-cyclin complex that is the engine that drives the cell cycle.
No takes yet. Share an insight, caveat, or question.
Ted Weinert (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: