Key result
Accidental high-dose intramyometrial vasopressin triggers severe, reversible bradycardia to ~25 bpm with marked peripheral vasoconstriction.
Why the study?
Predicting systemic effects of local vasopressin infiltration is difficult because reactions differ, and life-threatening complications can occur.
Case Report (n=1)
No
High-dose intramyometrial vasopressin infiltration can induce severe, potentially fatal baroreflex-mediated bradycardia and severe peripheral vasoconstriction, necessitating quantitative monitoring such as PPI.
High-dose intramyometrial vasopressin may trigger severe bradycardia; this case report leaves open the need for safer protocols and monitoring validation.
Vasopressin local infiltration is useful in gynecological surgery because it can reduce hemorrhage. Depending on the activities of the sympathetic system and the renin-angiotensin system, reactions to vasopressin may differ and predicting its systemic effects is difficult. Because life-threatening complications can occur, infiltration with vasopressin should be administered with caution. A 42-year-old female patient was diagnosed with uterine leiomyomas. During a robot-assisted laparoscopic myomectomy, 50 U of vasopressin, which is ten-times the recommended dose, was accidentally infiltrated. Subsequently, bradycardia with a heart rate of 25 bpm occurred, which recovered within 3 minutes. Peripheral perfusion indices and the diameter of the radial and brachial arteries also decreased markedly and recovered within 1 hour. The surgery was concluded without additional events. The patient was discharged 2 days later with no abnormal findings. Because vasopressin infiltration can cause life-threatening complications, it is necessary to determine the extent of patient reactions to vasopressin using measures such as the peripheral perfusion index or radial and brachial artery diameters. These measures may also help to predict the occurrence of complications.
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Kim et al. (2020) conducted a case report in Uterine leiomyomas (n=1). High-dose vasopressin infiltration was evaluated on Hemodynamic changes (heart rate, blood pressure, and peripheral perfusion index). Accidental intramyometrial infiltration of 50 U of vasopressin caused severe bradycardia (25 bpm) and marked decreases in peripheral perfusion and arterial diameters, which recovered within 1 hour.
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