Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers

Figures

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  Figure 1. Preparation of nanofibers with the electrospinning method and the osteogenesis in vitro process; reproduced from [33], with permission from [34].

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  Figure 2. Micro-CT 3D images representing whole sample: ‘‘simvastatin-containing PCL scaffolds”; PCL scaffold without simvastatin; ‘‘simvastatin-embedded PCL scaffolds”; and critical size defect without any scaffold (control group). (a) 3 months and (b) 6 months; reproduced with permission from [36].

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  Figure 3. (a) HUVEC migration in different nanofiber film environments after 6, 12, and 24 hours and (b) micrographs stained by crystal violet. (c) The NO release of HUVECs on different nanofiber films and (d) micrographs of fluorophore probe DAF-FMDA. ∗Significant difference of p < 0.05; reproduced with permission from [38].

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  Figure 4. (a) Schematic illustration showing the creation of the rabbit aneurysm model and a photograph showing aneurysm (arrow) formation during operation. (b) Schematic illustration showing aneurysm formation and an angiograph showing aneurysm (arrow). (c) Schematic illustration and an angiograph showing aneurysm closure after stent implantation. (d) Angiograph illustration types A, B, and C in the long-term follow-up. Bar graph showing the number of different types in the Rosu 100 group vs the PBS group; reproduced with permission from [40].

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  Figure 5. In vivo animal model for peripheral nerve injury on the sciatic nerve (a). A healthy sciatic nerve after surgical splitting of the muscles (b). Application of the Yasargil aneurism clip for trauma on the sciatic nerve (c). The sciatic nerve injury site after removal of the Yasargil aneurism clip (d). Implantation of composite nanofibers around the injured sciatic nerve just after the trauma (e). Scanning electron microscopy images of (e). Composite nanofibers containing ALA- and ATR-loaded chitosan nanoparticles (f). ATR-loaded chitosan nanoparticles existing in the composite nanofiber structure; reproduced with permission from [44].