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October 1, 1993Journal of Cellular Physiology

Porcine SMC secrete IGFBP-2 and IGFBP-4; insulin increased IGFBP-4 protein and mRNA, while IGF-I decreased intact IGFBP-4 in media by inducing its fragmentation, which prevented IGFBP-4 from inhibiting IGF-I-induced DNA synthesis in SMCs.

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Population

Porcine vascular smooth muscle cells (SMC) and human fibroblast cultures

Comparison

Treatment with insulin, IGF-I, IGF-II… vs Untreated cells or cells treated with IGF-I alone

Design

Preclinical

Authors

WCWendie S. CohickAGA GockermanDCDavid R. Clemmons

Discussion

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Overview

Does not inform clinical vascular management; hypothesis-generating for IGFBP-4 fragmentation in SMC growth and requires human validation.

Structured PICO

P
Population
Porcine vascular smooth muscle cells (SMC) and human fibroblast cultures
I
Intervention
Treatment with insulin, IGF-I, IGF-II, forskolin, dibutyryl cAMP, PDGF, FGF, EGF, TGF beta-1, and IGFBP-4
C
Comparator
Untreated cells or cells treated with IGF-I alone
O
Outcome
Secretion and mRNA levels of IGFBP-2 and IGFBP-4, and DNA synthesis (3H-thymidine incorporation)surrogate

Vascular smooth muscle cells secrete IGFBP-2 and IGFBP-4, which are differentially regulated by insulin and IGF-I, with IGF-I inducing fragmentation of IGFBP-4 to modulate its bioactivity.

Cite This Study

Cohick et al. (1993) studied this question.

synapsesocial.com/papers/6a6f3ca9e5469ee92be042cfhttps://doi.org/10.1002/jcp.1041570107
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