An efficient mild one‐pot protocol for the cross‐coupling of nitrones and alkynyl‐magnesium compounds using a catalytic amount of 2,2,6,6‐tetramethylpiperidine‐ N ‐oxyl radical (TEMPO) as an environmentally benign organic oxidant and dioxygen as terminal oxidant is described. These coupling reactions can be performed without adding any transition metal on various N ‐ tert‐ butylnitrones and alkynyl‐Grignard reagents. Moreover, the alkynylated nitrone products are readily transformed to regioisomerically pure 3,5‐disubstituted isoxazoles.
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Murarka et al. (2011) studied this question.
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