Femtomolar single-base mismatch discrimination: A nanoparticle-enhanced surface plasmon resonance imaging method for ultrasensitive detection of the selective hybridization between a peptide nucleic acid (PNA) oligomer and its complementary single-stranded DNA target is described. The method allows a 1 fM sensitivity in single-base mismatch discrimination with only 150 zeptomoles of the target molecules.
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D’Agata et al. (2008) studied this question.
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