Key result
In patients with primary aldosteronism, metanephrine provided a significantly higher Selectivity Index and a greater proportion of successful selective catheterization at baseline compared to cortisol.
Why the study?
The study investigated the usefulness of metanephrine and normetanephrine in bilateral simultaneous adrenal vein sampling with and without ACTH stimulation.
Does metanephrine improve the determination of catheterization selectivity in adrenal vein sampling compared to cortisol in patients with primary aldosteronism?
Observational (n=54)
No
Does metanephrine improve the determination of catheterization selectivity in adrenal vein sampling compared to cortisol in patients with primary aldosteronism?
Absolute Event Rate: 96.1% vs 74.5%
p-value: p=0.010
Metanephrine is superior to cortisol for determining catheterization selectivity during adrenal vein sampling in patients with primary aldosteronism, particularly in the absence of ACTH stimulation.
Metanephrine was associated with higher AVS selectivity than cortisol; leaves open whether it should replace cortisol as standard in primary aldosteronism.
The aim of the study was to investigate the usefulness of metanephrine (MN) and normetanephrine (NMN) in bilateral simultaneous adrenal vein sampling (AVS) with and without ACTH stimulation. The study was conducted in a single referral center. Prospective recruited patients with PA were treated with AVS. The effects of cortisol, MN and NMN on selectivity catheterization were assessed and determined by lateralization. We enrolled 54 patients with PA who were treated with simultaneous bilateral AVS with ACTH. The Selectivity Index (SI) calculated by MN was higher than that calculated by other indicators (p<0.001), the catheterization success rate of MN at baseline was the same as that of cortisol after ACTH stimulation, and in lateralization diagnosis, MN was not inferior to cortisol. In conclusion, among the studied indicators, MN is the best index for determining the catheterization selectivity in AVS, especially in the absence of ACTH stimulation.
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Liu et al. (2022) conducted an observational in Primary aldosteronism (n=54). Metanephrine vs. Cortisol was evaluated on Proportion of successful selective catheterization at baseline (left side) (p=0.010). In patients with primary aldosteronism, metanephrine provided a significantly higher Selectivity Index and a greater proportion of successful selective catheterization at baseline compared to cortisol.
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