Key result
Pregnant women with primary aldosteronism had a non-significant trend toward a higher incidence of pre-eclampsia (46.7% vs. 30.8%, p=0.252) compared to those without.
Why the study?
Primary aldosteronism is a common cause of hypertension in young women, but there is a paucity of data regarding its impact during pregnancy.
Does primary aldosteronism increase the incidence of hypertensive disorders of pregnancy in pregnant women?
Cohort (n=226)
No
Does primary aldosteronism increase the incidence of hypertensive disorders of pregnancy in pregnant women?
Primary aldosteronism during pregnancy trends toward increased risk for severe hypertensive disorders such as pre-eclampsia and postpartum hypertension, emphasizing the need for diagnostic vigilance in high-risk phenotypes.
OBJECTIVE: Primary aldosteronism (PA) is a common cause of hypertension in young women. However, there is a paucity of data regarding its impact during pregnancy. The primary objective of this study was to describe the occurrence of hypertensive disorders of pregnancy (HDP) in PA. DESIGN: This retrospective cohort study compared outcomes in pregnancies according to PA status. PATIENTS: Pregnancies occurred between 2011 and 2022 at the Centre Hospitalier Universitaire de Sherbrooke. All selected pregnancies were screened for PA with an aldosterone-to-renin ratio (ARR) within a 5-year period. Pregnancies with more than two fetuses and with other endocrinopathies were excluded. MEASUREMENTS: To ascertain PA diagnosis, ARR measurements were conducted, followed by a confirmatory test if abnormal. RESULTS: Among 226 studied pregnancies, 15 (6.6%) were diagnosed with PA. In the PA group, pre-eclampsia was diagnosed in 46.7% of pregnancies (vs. 30.8%, p = 0.252), while gestational hypertension was diagnosed in 0.0% of pregnancies (vs. 16.6%, p = 0.136). Post-partum HDP occurred in 40.0% of pregnancies with PA (vs 19.4%, p = 0.093). Additionally, 40.0% and 13.3% of pregnancies with PA respectively required intravenous antihypertensive treatment (vs. 24.2%, p = 0.216) and intensive care admission (vs. 3.3%, p = 0.113). CONCLUSIONS: A trend towards an increased incidence of postpartum and severe pre-eclampsia was noted in the PA group.
No takes yet. Share an insight, caveat, or question.
Oprea et al. (2025) conducted a cohort in Primary aldosteronism in pregnancy (n=226). Primary aldosteronism vs. No primary aldosteronism was evaluated on Pre-eclampsia (p=0.252). Pregnant women with primary aldosteronism had a non-significant trend toward a higher incidence of pre-eclampsia (46.7% vs. 30.8%, p=0.252) compared to those without.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: