Acute toxicity studies were made on 3 different samples of cottonseed pigment glands administered orally to 228 rats in the form of slurries made with either distilled water or 2% ferrous sulfate solution. The LD50 values for the samples when administered in water were, respectively, 1140, 1490 and 2290 mg/kg. When given in 2% ferrous sulfate solution the samples were detoxified so that even such high doses as 7000 mg/kg for each were no longer toxic. There was little effect on the body weight of all 99 rats which survived doses of ferrous sulfate-treated cottonseed pigment glands 3 to 6 times the LD50 value for water-suspended glands. Administration of pigment glands in 0.5% FeSO4 did not detoxify them, and led to the death of all 24 rats given this preparation.
No takes yet. Share an insight, caveat, or question.
Edward Eagle (1949) studied this question.