Thrombin binding and response in platelets from patients with dyslipoproteinemias: increased stimulus-response coupling in type II hyperlipoproteinemia

19 patients with various dyslipoproteinemias including familial hypercholesterolemia (type II, N=8), type V hyperlipoproteinemia (N=2), lecithin-cholesterol acyltransferase (LCAT) deficiency (N=2), abetalipoproteinemia (N=4), and Tangier disease (N=3).

In vitro exposure of washed platelets to 125I-thrombin (10^-10 to 10^-6 mol/L) and thrombin for aggregation (less than 10^-9 mol/L).

Normal platelets (reference ranges).

Thrombin binding and thrombin-induced platelet aggregation.surrogate