The best of both worlds: A combination of organocatalysis and transition-metal catalysis serve in the highly stereoselective and atom-economical reductive amination of a broad range of ketones. A chiral Brønsted acid catalyst facilitates the formation of protonated imines in situ and serves as chiral counteranion, while a chiral iridium complex catalyzes the reduction with elemental hydrogen.
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Martin Klußmann (2009) studied this question.
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