Key result
Physalis pubescens polysaccharide improves glucose tolerance, lipids, and antioxidant markers dose-dependently in diabetic mice.
) was found to be 20.0 kDa. It had a strong α-glucosidase inhibitory activity in vitro. PP treatment could enhance the oral glucose tolerance, and increase the levels of SOD, GSH, CAT, vitamin C, vitamin E, HDL-c, C-peptide, GCK and hepatic glycogen in diabetic mice. Besides, PP treatment could also decrease the levels of MDA, TG, TC, LDL-c, BUN and G-6-Pase. The regulating effects were stronger in high dose PP treatment than those in the low and medium dose treatments. In short, PP played an important role in protecting STZ-induced diabetic mice, and the effect was closely related to its activities in antioxidation and regulating glucose and lipid metabolism.
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Chen et al. (2019) studied STZ-induced diabetes. Physalis pubescens L. polysaccharide (PP) was evaluated. Treatment with a polysaccharide from Physalis pubescens L. enhanced oral glucose tolerance and improved antioxidant and lipid metabolism markers in STZ-induced diabetic mice in a dose-dependent manner.
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