Why the study?
Are serum angiotensin-converting enzyme (ACE) levels elevated in patients with HIV infection compared to HIV-negative controls?
Are serum angiotensin-converting enzyme (ACE) levels elevated in patients with HIV infection compared to HIV-negative controls?
Serum ACE levels are significantly elevated in patients with HIV infection, suggesting it may serve as a marker for the disease.
Elevated ACE in HIV may mark disease activity; leaves open its biomarker role pending prospective studies.
BACKGROUND: Serum angiotensin-converting enzyme (ACE) level is elevated in a number of disease states and medical conditions. Based on review of the medical literature, we postulated that serum ACE level elevation may occur during infection with the human immunodeficiency virus (HIV). METHODS: In a prospective, controlled study, serum ACE levels of HIV-positive patients were compared with those of an HIV-negative control population. RESULTS: Serum ACE levels were significantly elevated in patients with the acquired immunodeficiency syndrome (55.4 +/- 11.4 U/L) and in patients with an intermediate stage of HIV infection (57.2 +/- 25.3 U/L) when compared with levels in controls (31.9 +/- 14.0 U/L). CONCLUSIONS: Elevated serum ACE levels occur in HIV infection and may be an important marker for this disease.
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Daniel R. Ouellette (1992) studied this question.
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