Key result
In addition to traditional lipid variables, markers of oxidative stress were independently associated with both the thickness and echogenicity of the brachial artery intima-media complex.
Observational (n=1,016)
Markers of oxidative stress, along with traditional lipid variables, are independently associated with both thickness and echogenicity of the brachial artery intima-media complex in elderly subjects.
Oxidative stress markers may relate to brachial intima-media changes beyond lipids; hypothesis-generating in cross-sectional data and requires prospective validation.
The aim of the present study was to relate brachial artery intima-media thickness (IMT) and the grey scale median of the intima-media complex (IM-GSM) to traditional cardiovascular risk factors and markers of inflammation and oxidative stress. In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, a population-based study of 1016 subjects aged 70, brachial artery IMT and IM-GSM, who were evaluated by ultrasound. Lipids, thirteen markers of inflammation and nine markers of oxidative stress were measured. The Framingham risk score was related to IMT (p < 0.0001), but not to the IM-GSM. In univariate analysis, HDL-cholesterol, serum triglycerides, fasting glucose, smoking, HOMA insulin resistance index and oxidized LDL levels were related to IMT. HDL and LDL-cholesterol, triglycerides, VCAM-1, e-selectin, leukocyte count, conjugated diens, baseline conjugated diens (BCD)-LDL, antibodies to oxLDL, the GSSG/GSH glutathione ratio and homocysteine were related to IM-GSM. In multiple regression models, HDL-cholesterol, fasting glucose and oxLDL levels were the independently related to IMT (p = 0.01-0.04), while serum triglycerides, BCD-LDL and the GSSG/GSH ratio were independently related to IM-GSM (p = 0.0001-0.004). In conclusion, in addition to traditional lipid variables, markers of oxidative stress were associated with both thickness and echogenicity of the brachial artery intima-media complex. Thus, both thickness and echogenicity of the brachial artery intima-media complex might be useful biomarkers in the future.
No takes yet. Share an insight, caveat, or question.
Lind et al. (2007) conducted an observational in Cardiovascular risk (n=1,016). Lipids and markers of oxidative stress was evaluated on Brachial artery intima-media thickness (IMT) and grey scale median of the intima-media complex (IM-GSM). In addition to traditional lipid variables, markers of oxidative stress were independently associated with both the thickness and echogenicity of the brachial artery intima-media complex.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: