Eds Amir V Kaisary, Gerald P Murphy, Louis Denis, Keith Griffiths Martin Dunitz, £75, pp 384 ISBN 1 85317 422 X Rating: ![Graphic][1]![Graphic][2]![Graphic][3] The demonstration by Huggins and colleagues in 1941 of the effects of castration on prostate cancer was a breakthrough that won a Nobel prize and generated great optimism that cancer could be cured. As evidence gradually accumulated there was a reluctant realisation that hormone manipulation, despite its sometimes dramatic effects, is only a palliative treatment; there were to be few substantial advances in the management of prostate cancer … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
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NW Harrison (2000) studied this question.