l-Epinephrine administered intraperitoneally in rats caused a hyperuricemia, which can be inhibited by the pretreatments with alpha-adrenergic blockers, but not with betaadrenergic blockers. This was also inhibited by the pretreatments with ouabain, adrenochrome and allopurinol. The mechanism of the epinephrine-induced hyperuricemia was, therefore, considered to be due to the stimulation of ATP-degradation by epinephrine via alpha-adrenergic receptor.
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Yonetani et al. (1977) studied this question.