Synthesis of Marine Indole Alkaloids from Flustra foliacea

Brominated natural indoles are frequently reported metabolites of marine seaweeds. The bryozoan Flustra foliacea has been a rich source of brominated indole alkaloids bearing prenyl or isoprenyl substituents at various positions. Because interest in the chemistry of these marine alkaloids is steadily growing and shows unique promise in the discovery of new important medicinal drugs, the methods which have been employed towards their total synthesis are reviewed in detail.