Prevention of Type I Diabetes and Recurrent β-Cell Destruction of Transplanted Islets*

I. Introduction II. Disease Pathogenesis III. Disease Prediction A. Genetic prediction B. Immunological prediction C. Metabolic prediction IV. Prevention of Type I Diabetes A. Trial design B. Genetic prevention C. Prevention: preautoimmunity D. Prevention: postautoimmunity/prediabetes E. New onset patients/prevention of further β-cell destruction F. Pancreas and islet cell transplantation/prevention of recurrent diabetes G. Islet cell transplantation/prevention of β-cell destruction V. Conclusion