PURPOSE OF REVIEW: Sporadic inclusion body myositis (sIBM) is a poorly understood immune and degenerative disease of skeletal muscle. Here, current opinion of the nature of this disease is summarized. RECENT FINDINGS: Recent findings for sIBM include further characterization of muscle involvement through magnetic resonance imaging, the role of muscle as a host for immune cells, progress in the role of extranuclear TDP-43 in causing cellular injury, and the discovery of a new sIBM autoantibody. SUMMARY: sIBM understanding continues to advance, with progress regarding the mechanism of this disease.
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Steven A. Greenberg (2011) studied this question.
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