This review summarizes the characteristics and pathophysiologic implications of the cardiac T-type calcium current and its modulation by chemical agents.
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May guide T-type Ca channel research; leaves open therapeutic translation in arrhythmia or HF.
A low threshold, voltage-gated calcium current is reported in most cardiac tissues but rarely in ventricular cells. This article reports some recently described characteristics and discusses their possible pathophysiologic implications. It also reviews the alterations induced in this current by a variety of chemical agents including several neuromediators in cardiac and other tissues.
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Vassort et al. (1994) studied this question.
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