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To improve our understanding of phenobarbital (PB) mediated induction of CYP6D1 we examined the genetic linkage of PB induction using PB responsive (aabys) and non-responsive (LPR) strains of house flies. PB induction was linked to autosome 2, indicating that CYP6D1 is trans regulated by this PB inducible element. Our results are discussed relative to a previous hypothesis that the same regulatory genes are responsible for both induction and monooxygenase-mediated insecticide resistance.
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Liu et al. (1997) studied this question.
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