Single Protein Pores Containing Molecular Adapters at High Temperatures

Bearing the heat: Current has been measured from individual protein pores at temperatures approaching 100 °C. The molecular adapter β-cyclodextrin (red) remains bound to the α-hemolysin pore at high temperatures and retains the ability to bind guest molecules (black). Recording current at high temperatures is likely to be important for the study of single-molecule chemistry and in the development of stochastic sensors.