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October 1, 1998Synthesis

Synthesis of Perfluoroalkyl-Substituted Aryl Bromides and Their Purification Over Fluorous Reverse Phase Silica

Sabine Kainz Zhiyong Luo Dennis P. Curran Walter Leitner

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Abstract

(1H,1H,2H,2H-Perfluoroooctyl)-substituted aryl bromides 3a,b were synthesized via copper catalyzed cross-coupling of the iodide 1 with the corresponding arylmagnesium bromides 2a,b. A new, efficient method for the purification of highly fluorinated compounds by column chromatography on fluorous reverse phase silica is also described.

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Kainz et al. (1998) studied this question.

synapsesocial.com/papers/6a6f4bfbce524a4339c347f3 https://doi.org/10.1055/s-1998-2186

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