An ultrastructural modification of the sulfide‐silver method disclosed that rat and cattle eosinophilic granulocytes contain heavy metals in the non‐crystalloid parts of their specific granules and possibly also in the cell membrane. Metal analysis of isolated granules by means of atomic absorption spectrophotometry indicated that the principal metal contained in the granules is zinc. Consequently the metal demonstrated ultrastructurally in eosinophil granules is thought to be zinc.
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Pihl et al. (1967) studied this question.
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