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October 14, 2014Leukemia & lymphoma/Leukemia and lymphoma

Clinical impact of CD25 expression on outcomes of allogeneic hematopoietic stem cell transplant for cytogenetically intermediate-risk acute myeloid leukemia

Shuntaro Ikegawa Noriko Doki Keita Yamamoto Naoki Shingai Yukie Takahashi Jun Aoki Kosuke Yoshioka Kensuke Narukawa Shinya Ishida Aiko Igarashi Gaku Oshikawa Takeshi Kobayashi Kazuhiko Kakihana Hisashi Sakamaki Kyoko Haraguchi Yoshiki Okuyama Kazuteru Ohashi

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Abstract

Approximately 50% of adult patients with acute myeloid leukemia (AML) do not show clonal chromosome aberrations at diagnosis, and although this group shows an intermediate prognosis, a minority of ...

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Ikegawa et al. (2014) studied this question.

synapsesocial.com/papers/6a6f4d2eaf0c21e939276fa8 https://doi.org/10.3109/10428194.2014.974044

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?Prognostic Study · 2006 · 553 citations
2Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: recent advancesPrognostic Study · 2007 · 85 citations
3Acute Myeloid LeukemiaClinical Guideline · 2012 · 323 citations
4FLT3 internal tandem duplication in childhood acute myeloid leukaemia: association with hyperleucocytosis in acute promyelocytic leukaemiaPrognostic Study · 2002 · 64 citations
5CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900Late-Phase Clinical Trial · 2012 · 104 citations

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The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 Trial1998

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