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The report by Claxton et all describes a close correlation between the type of aberrant mRNA transcripts for PML/RAR-a in 2 1 patients with acute promyelocytic leukemia (APL) and expression of CD2, a surface antigen of the Ig superfamily of cellular adhesion molecules that is generally associated with a T-lymphocyte phenotype.2 Since we have recently studied a number of patients with APL using a battery of surface markers and reverse transcription polymerase chain reaction (RT/PCR) assay for PMLIRAR-a, we repeated this evaluation on a considerably larger data set. For this analysis, we used probes recently described3 to analyze mRNA extracted from leukemic bone marrow cells of 52 patients who presented to this center at the time of initial diagnosis or after relapse from cytotoxic chemotherapy. Flow cytometry was performed on Ficoll-Hypaque-separated mononuclear cells stained with a panel of commercially available monoclonal antibodies. Only fresh, nonfrozen samples were processed.
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Maslak et al. (1993) studied this question.
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