Key result
Fecal butyric acid, not blood levels, links to gut microbiota and prevalent type 2 diabetes.
Cohort (n=1,007)
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Blood metabolome is commonly used in human studies to explore the associations of gut microbiota-derived metabolites with cardiometabolic diseases. Here, in a cohort of 1007 middle-aged and elderly adults with matched fecal metagenomic (149 species and 214 pathways) and paired fecal and blood targeted metabolomics data (132 metabolites), we find disparate associations with taxonomic composition and microbial pathways when using fecal or blood metabolites. For example, we observe that fecal, but not blood butyric acid significantly associates with both gut microbiota and prevalent type 2 diabetes. These findings are replicated in an independent validation cohort involving 103 adults. Our results suggest that caution should be taken when inferring microbiome-cardiometabolic disease associations from either blood or fecal metabolome data.
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Deng et al. (2023) conducted a cohort in Cardiometabolic diseases (e.g., Type 2 diabetes) (n=1,007). Fecal and blood metabolome profiles was evaluated on Associations with taxonomic composition, microbial pathways, and cardiometabolic diseases. Fecal and blood metabolome data showed disparate associations with gut microbiota; fecal, but not blood, butyric acid significantly associated with both gut microbiota and prevalent type 2 diabetes.
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