Dual Microbiome Restoration as a Novel Therapeutic Strategy for Moderate-to-Severe Atopic Dermatitis

This study investigates the therapeutic potential of microbiome-targeted interventions for moderate-to-severe atopic dermatitis through a comprehensive clinical trial evaluating both skin and gut microbiome modulation. The randomized controlled study compared three treatment approaches: oral probiotic supplementation, topical application of commensal skin bacteria, and a combination of both therapies, against standard care in 65 patients over 12 weeks. Clinical assessments demonstrated superior