Key result
Sacha inchi oil supplementation (15 mL) added to a high-fat meal attenuated glucose increases in 38.1% of healthy men and correlated with postprandial insulin sensitivity (r=0.636; p=0.035).
Why the study?
Does Sacha inchi oil supplementation improve postprandial glycemic state and insulin sensitivity in healthy adult men consuming a saturated fat-rich meal?
RCT (n=42)
Double blind
randomized
Does Sacha inchi oil supplementation improve postprandial glycemic state and insulin sensitivity in healthy adult men consuming a saturated fat-rich meal?
Effect estimate: r = 0.636
p-value: p=0.035
The addition of Sacha inchi oil to a high-fat meal may improve insulin sensitivity and correlate with sirtuin-1 expression in men with higher basal triglyceridemia.
BACKGROUND: The postprandial stage is related to cardiovascular risk and it depends on the type of meal consumed. We study the effects of Sacha inchi oil on the postprandial glycemic state caused by meals rich in saturated fat. METHODS AND RESULTS: A double blind randomized trial in which 42 adult men ingested two breakfasts rich in saturated fat, one of them containing additionally 15 mL of Sacha inchi oil. Blood samples were obtained before or after 1 and 4 hours post-ingestion to quantify glucose, insulin and lipid profile in serum. The insulinogenic and sensitivity indices were calculated and the expression of sirtuin-1 in circulating mononuclear cells by qPCR was determined. RESULTS: Oil addition attenuated the increase of glucose in 16 (38.1%) participants. This group showed a higher concentration of fasting triacylglycerides and sirtuin-1 expression at 4 hours post-Sacha inchi oil correlated with glucose at the same time (r = -0.724; p = 0.012), and with postprandial insulin sensitivity (r = 0.636; p = 0.035). CONCLUSIONS: The addition of Sacha inchi oil to a highly fatty meal improves insulin sensitivity in people with higher basal triglyceridemia and higher glycemic responses after a fat load. Under these conditions, sirtuin-1 expression correlates with postprandial insulin sensitivity.
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Alayón et al. (2018) conducted an RCT in Healthy subjects (n=42). Sacha inchi oil vs. Breakfast rich in saturated fat without Sacha inchi oil was evaluated on Postprandial glucose increase and sirtuin-1 expression correlation with insulin sensitivity (r = 0.636, p=0.035). Sacha inchi oil supplementation (15 mL) added to a high-fat meal attenuated glucose increases in 38.1% of healthy men and correlated with postprandial insulin sensitivity (r=0.636; p=0.035).
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