The bioactive principles present in oil bean (Pentaclethra marophyllabenth) and their effects in the haematological and biochemical profile of male albino wistar rats were studied using 22 male albino wistar rats weighing 180–200g. The study is aimed at ascertaining the impact of prolonged administration of Pentaclethra macrophyllabenth on the haematological and biochemical profile of albino wistar rats. The 22 male albino rats were acclimatized in the animal house for 14 days. After this, they were divided into three groups (A, B, and C) respectively. Group A was the control group (6 rats), Group B (8 rats) on low dose of the extracts, while Group C (8 rats) on high dose of the extract. Group B and C received the extract for 28 days while Group A received normal rat feed and water ad libitum. Blood samples were collected from the animals by cardiac puncture and placed in E.D.T.A (Ethylene diamine tetracetic acid) and in plain tubes for the analysis. Results showed that Pentaclethra macrophyllabenth increased the haemoglobin concentration, packed cell volume, platelet count, and WBC count. It also caused elevation of the liver function profiles in the test rats due to prolonged administration. It could be deducted from this research that the extract of Pentaclethra macrophyllabenth contains some bioactive principles capable of altering the biochemical and haematological profile of rats.
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Oguwike et al. (2020) studied this question.
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