Key result
Whole-genome sequencing of FMDV serotype O/PanAsia-2/QOM-15 showed higher sequence similarity (91.00%) and antigenic relationship (29.00%) with O/PanAsia-2 than with O/PanAsia.
The alteration of virus antigenicity and lack of detectable adaptive pressure on the VP1 sequence suggest that studying genetic dynamics beyond the VP1 region is necessary to evaluate FMDV pathogenicity and vaccine failure.
Antigenicity shifts without VP1 selection pressure may necessitate updated vaccines; leaves open broader genomic drivers of FMDV evolution.
, 2C, and 3A). The O/PanAsia-2/QOM-15 shared higher sequence similarity with O/PanAsia-2 (91.00%) compared to O/PanAsia (87.30%). Evaluating r-value showed that the antigenic relationship of O/PanAsia-2/QOM-15 with O/PanAsia-2 (29.00%) was greater than that of the O/PanAsia (24.00%); however, all three viruses were immunologically distinct. After 10 years, the alteration of virus antigenicity and the lack of detectable adaptive pressure on VP1 sequence suggest that studying genetic dynamics beyond the VP1 region is necessary to evaluate FMDV pathogenicity and vaccine failure.
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Gadir et al. (2023) studied Foot-and-mouth disease virus (FMDV). Whole-genome sequencing of FMDV serotype O/PanAsia-2/QOM-15 vs. O/PanAsia-2 and O/PanAsia vaccine strains was evaluated on Sequence similarity and antigenic relationship (r-value). Whole-genome sequencing of FMDV serotype O/PanAsia-2/QOM-15 showed higher sequence similarity (91.00%) and antigenic relationship (29.00%) with O/PanAsia-2 than with O/PanAsia.
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