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April 1, 1970Journal of General Virology

Replication of Foot-and-Mouth Disease Virus Ribonucleic Acid

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Population

Baby hamster kidney cells infected with foot-and-mouth disease virus

Comparison

Heat and formaldehyde treatment vs 35s RNA extracted from purified virus treated…

Design

Preclinical

Authors

TWThorsten WildNokia (Finland)FBF. BrownMaryland Institute College of Art

Discussion

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Implication

No direct clinical implications for cardiovascular care; leaves open whether RNA size influences viral replication in animal models.

Structured PICO

P
Population
Baby hamster kidney cells infected with foot-and-mouth disease virus
I
Intervention
Heat and formaldehyde treatment (6% formaldehyde in 0.01 m-EDTA at 37° and 70°)
C
Comparator
35s RNA extracted from purified virus treated similarly
O
Outcome
Sedimentation properties of virus RNAsurrogate

This basic science study elucidates the structural properties of foot-and-mouth disease virus RNA, suggesting the ribonuclease-resistant RNA may exist as a circular molecule.

Cite This Study

Wild et al. (1970) studied this question.

synapsesocial.com/papers/6a6f57d4ac440176ef2808fdhttps://doi.org/10.1099/0022-1317-7-1-1
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A study of the heterogeneous 37s ribonucleic acid induced by foot-and-mouth-disease virus1968 · 10 citations
  2. 2An intermediate in the synthesis of poliovirus RNA.1966 · 126 citations
  3. 3The effect of reaction with formaldehyde on the sedimentation rates of ribonucleic acids1968 · 58 citations